In the wake of several near-cataclysmic events, humanity created the Cure, a DNA-altering antidote to death by disease and old age. But all cures come with side effects: a small percentage of the population develops a wide range of powers, some lethal to others and some lethal to the wielder.

These people are called the Estranged, hunted and shunned, safe only on the Island of Exile. It is here that Kaeva and Eddie meet ... and where they set a prophecy in motion, quite possibly sealing their own demise, and even the end of Exile.